@article {Kamgno:2009yq,
	title = {Loa loa microfilarial periodicity in ivermectin-treated patients: comparison between those developing and those free of serious adverse events.},
	journal = {Am J Trop Med Hyg},
	volume = {81},
	number = {6},
	year = {2009},
	pages = {1056{\textendash}1061},
	address = {Filariasis Research Centre, Yaounde, Cameroon. jkamgno{\char64}yahoo.fr},
	abstract = {The main risk factor of post-ivermectin serious adverse events (SAEs) is the presence of a high Loa loa microfilaremia. However, the majority of patients with such high loads do not develop SAEs, suggesting that co-factors may be involved. An infection with simian Loa parasites, whose microfilariae show a nocturnal periodicity, might be such a co-factor. The periodicity of Loa microfilariae was compared, using cosinor methodology, in 4 patients who had developed a post-ivermectin neurologic SAE, 4 patients who had experienced a non-neurologic SAE, and 14 control individuals. The periodicity was similar in all three groups, with a peak of microfilaremia occurring between 12:30 and 2:00 PM. The results of this study, which for the first time characterizes the periodicity of Loa microfilariae mathematically, suggest that post-ivermectin SAEs are not related to an infection with a Loa simian strain.},
	issn = {1476-1645 (Electronic); 0002-9637 (Linking)},
	doi = {10.4269/ajtmh.2009.09-0356},
	author = {Kamgno, Joseph and Pion, Sebastien D and Mackenzie, Charles D and Thylefors, Bjorn and Boussinesq, Michel}
}
