01785nas a2200217   4500008004100000245009700041210006900138260009000207300001200297490000700309520095200316653002401268653002601292653002301318653001901341653002001360653003401380100002001414700001501434856011801449       2004                        eng d00aA comparison of methods for estimating the transition: transversion ratio from DNA sequences0 acomparison of methods for estimating the transition transversion  a525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USAbACADEMIC PRESS INC ELSEVIER SCIENCE  a495-5030 v323 aEstimation of the ratio of the rates of transitions to transversions (TI:TV ratio) for a collection of aligned nucleotide sequences is important because it provides insight into the process of molecular evolution and because such estimates may be used to further model the evolutionary process for the sequences under consideration. In this paper, we compare several methods for estimating the TI:TV ratio, including the pairwise method [TREE 11 (1996) 158], a modification of the pairwise method due to Ina [J. Mol. Evol. 46 (1998) 521], a method based on parsimony (TREE 11 (1996) 158), a method due to Purvis and Bromham [J. Mol. Evol. 44 (1997) 112] that uses phylogenetically independent pairs of sequences, the maximum likelihood method, and a Bayesian method [Bioinformatics 17 (2001) 754]. We examine the performance of each estimator under several conditions using both simulated and real data. (C) 2004 Elsevier Inc. All rights reserved.10aBayesian estimation10aindependent contrasts10amaximum likelihood10arate variation10atransition bias10atransition/transversion ratio1 aStrandberg, AKK1 aSalter, LA  uhttps://nematoda.myspecies.info/content/comparison-methods-estimating-transition-transversion-ratio-dna-sequences