01484nas a2200181   4500008004100000245003700041210003700078260008100115300001200196490000700208520090200215653002201117653002701139653002901166653001801195100001501213856007401228       2002                        eng d00aMapping mutations on phylogenies0 aMapping mutations on phylogenies  a325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USAbTAYLOR & FRANCIS INC  a729-7390 v513 aMapping of mutations on a phylogeny has been a commonly used analytical tool in phylogenetics and molecular evolution. However, the common approaches for mapping mutations based on parsimony have lacked a solid statistical foundation. Here, I present a Bayesian method for mapping mutations on a phylogeny. I illustrate some of the common problems associated with using parsimony and suggest instead that inferences in molecular evolution can be made on the basis of the posterior distribution of the mappings of mutations. A method for simulating a mapping from the posterior distribution of mappings is also presented, and the utility of the method is illustrated on two previously published data sets. Applications include a method for testing for variation in the substitution rate along the sequence and a method for testing whether the d(N)/d(s) ratio varies among lineages in the phylogeny.10adata augmentation10aDNA sequence evolution10aMarkov chain Monte Carlo10aphylogenetics1 aNielsen, R  uhttps://nematoda.myspecies.info/content/mapping-mutations-phylogenies