01761nas a2200193   4500008004100000022004800041245014800089210006900237260007600306300001600382490000700398520091300405100001901318700002301337700002601360700002101386700002301407856013701430       2009                        eng d  a1476-1645 (Electronic); 0002-9637 (Linking)00aLoa loa microfilarial periodicity in ivermectin-treated patients: comparison between those developing and those free of serious adverse events.0 aLoa loa microfilarial periodicity in ivermectintreated patients   aFilariasis Research Centre, Yaounde, Cameroon. jkamgno{\char64}yahoo.fr  a1056–10610 v813 aThe main risk factor of post-ivermectin serious adverse events (SAEs) is the presence of a high Loa loa microfilaremia. However, the majority of patients with such high loads do not develop SAEs, suggesting that co-factors may be involved. An infection with simian Loa parasites, whose microfilariae show a nocturnal periodicity, might be such a co-factor. The periodicity of Loa microfilariae was compared, using cosinor methodology, in 4 patients who had developed a post-ivermectin neurologic SAE, 4 patients who had experienced a non-neurologic SAE, and 14 control individuals. The periodicity was similar in all three groups, with a peak of microfilaremia occurring between 12:30 and 2:00 PM. The results of this study, which for the first time characterizes the periodicity of Loa microfilariae mathematically, suggest that post-ivermectin SAEs are not related to an infection with a Loa simian strain.1 aKamgno, Joseph1 aPion, Sebastien, D1 aMackenzie, Charles, D1 aThylefors, Bjorn1 aBoussinesq, Michel  uhttps://nematoda.myspecies.info/content/loa-loa-microfilarial-periodicity-ivermectin-treated-patients-comparison-between-those-devel